Thrombin Mediates Severe Neurovascular Injury During Ischemia
نویسندگان
چکیده
منابع مشابه
Thrombin mediates severe neurovascular injury during ischemia.
BACKGROUND AND PURPOSE Cerebral ischemia initiates cascades of pathological events such as edema, blood-brain barrier breakdown, and tissue degeneration. Thrombin activation is a key step in coagulation, and thrombin has recently been shown to mediate endothelial permeability and cellular toxicity in vitro. We examined the effect of thrombin on vasculature during ischemia in vivo. METHODS Foc...
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ژورنال
عنوان ژورنال: Stroke
سال: 2010
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.110.584920